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Abstract # 3198 Development of Novel Multifunctional Nanoparticles for Combined Imaging and Targeted Delivery of Chemoradiotherapy

Presenter: Wang, Andrew

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Results:
These polymer‐lipid nanoparticles have hydrodynamic diameter of 70+/‐5 nm, zeta potential of ‐40+/‐5 mV. The seven‐day release profile of docetaxel showed a first‐order release kinetic. Using 111In as the radioisotope, we showed the nanoparticles’ chelation efficiency was 99+/‐0.5%. The seven‐day chelate stability study showed no release of the chelate in the first 36 hours, and approximately a 50% release after 120 hours. As proof of principle, we used prostate cancer as a model and conjugated the A10 RNA aptamer that binds the prostate specific membrane antigen (PSMA) to the nanoparticles. We demonstrated the targeted uptake of these nanoparticles using LNCaP (PSMA+) and PC3 (PSMA‐) prostate cancer cells. Using 90Y, we also demonstrated the efficacy of concurrent chemoradiotherapy nanoparticles is superior than either chemotherapy nanoparticles or radiotherapy nanoparticles. Using 111In, We were able to study the biodistribution of the particles and track the particles using SPECT‐CT imaging in vivo.