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Results:
Forty‐one (11.2%) patients developed grade 2 proctitis: 51% within the first year of completing EBRT, 42% between the first and second year, and 7% within the third year. The median prostate D90 was 104 Gy (range 53‐145). The median BED was 202 Gy (range 142‐256). A median of 0.42 cc (range 0‐3.1) of rectal wall was covered by the V100. 60 patients (16.4%) had > 1.0 cc covered. The development of Grade 2 proctitis was not dependent on the volume of rectal tissue receiving the prostate prescription dose. The actuarial rate for proctitis when 100 Gy was delivered to < 1.0 cc of rectal tissue was 12% at 5 years compared to 13% when the irradiated rectal volume was > 1.0 cc (p=0.8). Similar proctitis rates were found when volume cutpoints of 0.4, 0.5, 0.75, and 1.5 cc were examined. No significant difference in proctitis was noted when examining the volume of rectal tissue that received either 80% or 150% of the prostate prescription dose. 5‐year proctitis rates by BED groups were 9.3% (<200), 13.7% (200‐219.9), and 16.2% (> 220, p=0.327).
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