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Abstract # 2271 Long term Outcomes for Patients with Gleason Scores 8-10 Prostate Cancer Treated with Combination Brachytherapy, External Beam Irradiation and Hormonal Therapy

Presenter: Stock, Richard

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Materials/Methods:
From 1994 ‐ 2005, 177 patients with Gleason scores 8 ‐10 prostate cancer were treated with 9 months of hormonal therapy in combination with Pd‐103 (prescription dose ‐ 100Gy) prostate brachytherapy and external beam irradiation (median dose ‐ 45Gy). Biologically effective dose values (BED) were calculated for all treatments from the one month CT dosimetry D90 using and α/β ratio of 2. Presenting PSA levels were < 10 in 54%, >10‐20 in 27% and >20 in 19%. Gleason scores were 8 in 67% and 9‐10 in 33%. Clinical stage was < t1c in 19%, t2a in 10%, t2b in 32%, t2c in 24% and t3 in 15%. Follow‐up ranged from 2 to 11 years (median ‐ 5).