Abstract # 2193 Quality of Life during Adjuvant Chemoradiation for Gastric Adenocarcinoma

Presenter: Ringash, Jolie

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Thirty‐three of 34 English‐speaking patients in the study were eligible for QOL evaluation (cohort 1 [n=6]; 2[9]; 3[7], 4[6]; 5[5]). The European Organisation for Research and Treatment of Cancer (EORTC) QLQC30 was completed before CRT, at completion of radiation, then 4 weeks, 6 to 12 months, and 2 to 3 years after completion of chemotherapy. Endpoints were global QOL and functional scales (physical, role, emotional, cognitive, social), with a 10‐point difference on a 1‐100 scale considered clinically significant. Exploratory analyses were conducted to compare QOL in 5 patients experiencing dose‐limiting toxicity (DLT) [>grade 2 toxicity requiring treatment or hospitalization] to mean scores in the remaining patients, and to assess the association of QOL with dose cohort using the linear mixed model.