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Abstract # 2929 Region of Interest Analysis as a Tool for Exploring Adaptive IMRT Strategy for Cervix Cancer Patients

Presenter: Cho, Young-Bin

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About the Presenter:
Young-Bin Cho, PhD, MCCPM, Physicist Princess Margaret Hospital Assistant Prof. Dep of Radiation Oncology, Univ of Toronto. My research interest includes the application of image guidance, functional imaging, adaptive radiation therapy considering organ deformation and gamma knife stereotatic radiation treatment. My PhD study was to develop an intelligent image processing system including a novel cone beam CT system for industrial purpose. I have several patents from my research during my PhD and postdoctoral studies. Robotics, machine vision, image processing, and artificial intelligence were the topics that I had been working on for my PhD. Postdoctoral research was to develop a kilovoltage x ray imaging system on LINAC, currently popular cone beam CT system on LINAC. During my physics residency, I have been involved in many interesting research topics including (1) Geometric calibration of cone beam systems, (2) functional imaging and (3) Organ deformation and its dosimetric effect using FEM analysis. "Geometric calibration of cone beam systems" was patented. The technique originally developed for kV cone-beam CT system on was found to be fully general and could be used to calibrate MV treatment system. The functional CT for the disease of prostate, cervix, lung and brain can be potentially used for biological adaptive radiation therapy. Currently I am investigating the potential of cone beam CT system on LINAC for functional imaging. Due to the slow scan of the system, a novel reconstruction method should be developed. Feasibility study showed a great potential of functional cone beam CT system and the developed algorithm can be used for conventional fCT to significantly reduce the dose to the patient. Searching for the optimal reconstruction method as well as accelerating the reconstruction procedure is my major interest for current functional CT studies. The understanding of the organ motion and deformation is essential for high precision imaging study and radiation therapy. Prostate deformation due to the TRUS probe was analyzed using commercial FEM program, ANSYS. Adaptive radiation therapy considering organ motion and deformation is very important step to enhance the performance of the radiation therapy. Gynaecological cancer patients were under reivew in my institution in a hope for the potential benefit of the adaptive radiation therapy.
Contact the presenter at: young-bin.cho@rmp.uhn.on.ca

Authors:
Y. Cho1, J. Xie1, V. Kelly1, K. Lim1, J. Stewart1, A. Fyles1, K. Brock1, A. Lundin2, H. Rehbinder2, M. Milosevic1, 1Princess Margaret Hospital, Toronto, ON, Canada, 2RaySearch Laboratories, Stockholm, Sweden

Author Disclosure:
 Y. Cho, None; J. Xie, None; V. Kelly, None; K. Lim, None; J. Stewart, None; A. Fyles, None; K. Brock, None; A. Lundin, None; H. Rehbinder, None; M. Milosevic, None.


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