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Our results indicate that a strategy of genomic screening to identify promoters for IR inducible gene therapy is feasible. Also there appears to be an interplay of Ad and IR to enhance transcription from certain promoters, ie GDF15. Studies are currently underway to further exploit this approach.
Author Disclosure: S.J. Advani, None; N.N. Khodarev, None; T. Darga, None; C. Weichselbaum, None; M. Beckett, None; R.R. Weichselbaum, GenVec, F. Consultant/Advisory Board.